While I'm a little unsure about the Skill/SPECIAL changes I don't think I'll mind them.
I mean skills were sort of pointless really, level up by killing a load of raiders, then suddenly throw some points into speech and smooth talk your way through the game with 1 Charisma?
Be dumb as a brick with 1 intelligence but all those locks you picked taught you how to hack a computer and do advanced scientific stuff with no prior experience?
Your special stats weren't really all that important apart from a few speech checks and as requirements for a few perks that could easily by skipped anyway, this system seems like it's going to make your initial character creation much more important, it actually matters what you're good at.
Everything else on that list looks like nothing but improvements, except for maybe how radiation is handled now, I quite liked the reduction to SPECIAL stats, but did also want some HP damage from it, which would have made more sense.
**** the radial weapons wheel though, ****ing consoles.