Legs and feet are always good targets. I tend to also go for the upper and lower body. Windedness and nausea are incredibly useful debuffs.
True that. Something I've also found useful are heavy lower body slashes. About half the time, it'll spill the guts. Then, aim a precise slash at the guts themselves, since they're now unprotected. It'll sever the guts, which is essentially a mortal wound. It causes nausea, and the bleeding will never stop.